Structural Lipids Stabilise Functional Oligomers of the Eukaryotic Purine Symporter UapA
نویسندگان
چکیده
منابع مشابه
Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity
The uric acid/xanthine H(+) symporter, UapA, is a high-affinity purine transporter from the filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a genetically stabilized version of UapA (UapA-G411VΔ1-11) in complex with xanthine. UapA is formed from two domains, a core domain and a gate domain, similar to the previously solved uracil transporter UraA, which belongs ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.3758